In view of the need for accelerated solutions for Covid-19, the Ministry of AYUSH has taken up systematic studies on different possible solutions through multiple channels. As part of this effort,Â a proposal for a clinical studyÂ to assessÂ the role ofÂ Vasa Ghana, Guduchi GhanaÂ andÂ Vasa-Guduchi GhanaÂ in therapeutic management of symptoms in Covid-19 positive cases has recently been approved. This will be a â€œrandomized, open label three armedâ€ study, and will be conducted at the All India Institute of Ayurveda (AIIA), New Delhi, in collaboration with the IGIB unit of CSIR.
The detailed proposal with methodology including outcome measures, clinical andÂ laboratory parameters, the logistics of the research has been prepared. The study will use a unique Case Report Forum (CRF), suitable for Ayush mode research. The CRF and study protocol has also beenÂ peer reviewed by experts from different domains including modern medicine and their suggestions have been incorporated.Â The study will be undertaken subject to the required approvals like that of the Institutional Ethics Committee (IEC).
The project would look into the following specific considerations:
The efficacy/action of mono-herbal formulations of whole extracts ofÂ VasaÂ andÂ GuduchiÂ respectively, and polyherbal formulation ofÂ Vasa-GuduchiÂ whole extract on therapeutic management of SARS-CoV2 positive asymptomatic and/ or mild Covid-19 symptomatic cases. The impact of the said formulations on the speed of viral replication.
Whether the said mono-herbal and polyherbal formulations can alter the expression profiles of keyÂ bio markers associated with Covid-19 disease.
VasaÂ andÂ GuduchiÂ are time tested herbs in Indian healthcare traditions, used in a variety of disease conditions. The outcome of this study would therefore be of considerable interest to the entire Ayush Sector.